2021-22 Buffalo Sabres (32-39-11)

14 Oct W Montreal 5- 1  
(1-0-0)
16 Oct W Arizona 2- 1 (S)
(2-0-0)
19 Oct W Vancouver 5- 2  
(3-0-0)
22 Oct L Boston 1- 4  
(3-1-0)
23 Oct OL at New Jersey 1- 2 (O)
(3-1-1)
25 Oct W Tampa Bay 5- 1  
(4-1-1)
28 Oct W at Anaheim 4- 3 (O)
(5-1-1)
31 Oct L at Los Angeles 2- 3  
(5-2-1)
2 Nov L at San Jose 3- 5  
(5-3-1)
4 Nov L at Seattle 2- 5  
(5-4-1)
6 Nov OL Detroit 3- 4 (O)
(5-4-2)
8 Nov L at Washington 3- 5  
(5-5-2)
12 Nov W Edmonton 3- 2  
(6-5-2)
13 Nov L Toronto 4- 5  
(6-6-2)
16 Nov W at Pittsburgh 2- 1  
(7-6-2)
18 Nov L Calgary 0- 5  
(7-7-2)
21 Nov L at NY Rangers 4- 5  
(7-8-2)
22 Nov L Columbus 4- 7  
(7-9-2)
24 Nov L Boston 1- 5  
(7-10-2)
26 Nov W Montreal 4- 1  
(8-10-2)
27 Nov OL at Detroit 2- 3 (O)
(8-10-3)
29 Nov L Seattle 4- 7  
(8-11-3)
2 Dec L at Florida 4- 7  
(8-12-3)
4 Dec L at Carolina 2- 6  
(8-13-3)
7 Dec L Anaheim 0- 2  
(8-14-3)
10 Dec L NY Rangers 1- 2  
(8-15-3)
11 Dec SL Washington 2- 3 (S)
(8-15-4)
14 Dec W at Winnipeg 4- 2  
(9-15-4)
16 Dec W at Minnesota 3- 2 (S)
(10-15-4)
17 Dec OL at Pittsburgh 2- 3 (O)
(10-15-5)
29 Dec L New Jersey 3- 4  
(10-16-5)
30 Dec L at NY Islanders 1- 4  
(10-17-5)
1 Jan OL at Boston 3- 4 (O)
(10-17-6)
6 Jan L San Jose 2- 3  
(10-18-6)
11 Jan L Tampa Bay 1- 6  
(10-19-6)
13 Jan W at Nashville 4- 1  
(11-19-6)
15 Jan L at Detroit 0- 4  
(11-20-6)
17 Jan OL Detroit 2- 3 (O)
(11-20-7)
18 Jan W at Ottawa 3- 1  
(12-20-7)
20 Jan L Dallas 4- 5  
(12-21-7)
22 Jan W Philadelphia 6- 3  
(13-21-7)
25 Jan L at Ottawa 0- 5  
(13-22-7)
29 Jan W at Arizona 3- 1  
(14-22-7)
30 Jan L at Colorado 1- 4  
(14-23-7)
1 Feb L at Vegas 2- 5  
(14-24-7)
10 Feb OL Columbus 3- 4 (O)
(14-24-8)
13 Feb W at Montreal 5- 3  
(15-24-8)
15 Feb W NY Islanders 6- 3  
(16-24-8)
17 Feb L Ottawa 1- 3  
(16-25-8)
19 Feb L Colorado 3- 5  
(16-26-8)
20 Feb L at Columbus 3- 7  
(16-27-8)
23 Feb L at Montreal 0- 4  
(16-28-8)
25 Feb L at St Louis 3- 5  
(16-29-8)
27 Feb L at Dallas 2- 4  
(16-30-8)
2 Mar W at Toronto 5- 1  
(17-30-8)
4 Mar W Minnesota 5- 4  
(18-30-8)
6 Mar L Los Angeles 0- 3  
(18-31-8)
7 Mar L Florida 1- 6  
(18-32-8)
10 Mar W Vegas 3- 1  
(19-32-8)
13 Mar W Toronto 5- 2  
(20-32-8)
17 Mar L at Edmonton 1- 6  
(20-33-8)
18 Mar W at Calgary 1- 0 (O)
(21-33-8)
20 Mar W at Vancouver 3- 2 (O)
(22-33-8)
23 Mar W Pittsburgh 4- 3 (S)
(23-33-8)
25 Mar SL Washington 3- 4 (S)
(23-33-9)
27 Mar OL at NY Rangers 4- 5 (O)
(23-33-10)
28 Mar W at Chicago 6- 5  
(24-33-10)
30 Mar SL Winnipeg 2- 3 (S)
(24-33-11)
1 Apr W Nashville 4- 3  
(25-33-11)
3 Apr L Florida 3- 5  
(25-34-11)
5 Apr W Carolina 4- 2  
(26-34-11)
7 Apr L at Carolina 3- 5  
(26-35-11)
8 Apr L at Florida 3- 4  
(26-36-11)
10 Apr L at Tampa Bay 0- 5  
(26-37-11)
12 Apr W at Toronto 5- 2  
(27-37-11)
14 Apr L St Louis 2- 6  
(27-38-11)
16 Apr W Philadelphia 4- 3  
(28-38-11)
17 Apr W at Philadelphia 5- 3  
(29-38-11)
21 Apr W at New Jersey 5- 2  
(30-38-11)
23 Apr W NY Islanders 5- 3  
(31-38-11)
28 Apr L at Boston 0- 5  
(31-39-11)
29 Apr W Chicago 3- 2 (O)
(32-39-11)