1980-81 Notre Dame (22-6) Independents

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29 Nov L at UCLA 81- 94
(0-1)
2 Dec W Montana St 87- 68
(1-1)
4 Dec W TCU 79- 63
(2-1)
9 Dec W Indiana 68- 64
(3-1)
22 Dec W Valparaiso 69- 56
(4-1)
27 Dec W at Kentucky 67- 61
(5-1)
4 Jan W at Davidson 87- 67
(6-1)
6 Jan W at Villanova 96- 65
(7-1)
10 Jan L at Marquette 52- 54
(7-2)
13 Jan L at San Francisco 63- 66
(7-3)
17 Jan W Hofstra 65- 55
(8-3)
19 Jan W Fordham 67- 61
(9-3)
21 Jan W San Francisco 80- 75
(10-3)
24 Jan W at Maryland 73- 70
(11-3)
27 Jan W Cornell 80- 58
(12-3)
31 Jan W South Carolina 94- 84
(13-3)
2 Feb W St Marys 94- 63
(14-3)
4 Feb W La Salle 60- 59
(15-3)
8 Feb L UCLA 50- 51
(15-4)
10 Feb W Boston U 89- 63
(16-4)
14 Feb W at North Carolina St 71- 55
(17-4)
16 Feb W Fairfield 57- 55
(18-4)
22 Feb W Virginia 57- 56
(19-4)
26 Feb W St Francis-PA 87- 71
(20-4)
28 Feb W Dayton 70- 57
(21-4)
8 Mar L at DePaul 64- 74
(21-5)
14 Mar W vs James Madison 54- 45
(22-5)
19 Mar L vs BYU 50- 51
(22-6)